A key failing of the normal uric acid calculation is the inclusion of sick people.
To explain, when labs calculate normal uric acid statistics they use test results from “healthy” people. So they exclude people who are known to have gout. But they don’t exclude people with high uric acid if they are not diagnosed with gout.
Now I’ve always maintained that this is wrong. Because uric acid levels above 6.8 mg/dL without gout symptoms is a recognized illness – asymptomatic hyperuricemia. So any results higher than 6.8 should be excluded when the labs calculate the normal range statistics. Then we would know the true normal uric acid range for healthy people. Unfortunately, this is not the case.
True Normal Uric Acid Range
I’ve often wondered how uric acid reference ranges would look if they were calculated correctly. So I’m pleased to learn of a study that has done exactly that.
Though this isn’t a gout study, the researchers were keen to restrict their investigation to healthy people. So they eliminated any uric acid results from people with:
- Uric acid above 6.8 mg/dL
- Diagnosis of gout and other associated illnesses. Such as diabetes, hypertension, heart disease, and kidney disease.
- Use of allopurinol, probenecid, and drugs associated with the other diseases.
Also, people with factors associated with diabetes were excluded. Then the researchers performed statistical analysis. Separating male and female groups before analyzing diabetes incidence.
Most significantly, in order to complete their analysis, the researchers needed to calculate reference ranges for the healthy men and women they were studying. So they derived the following true normal uric acid ranges:
- Men from 3.0 to below 4.0 mg/dL
- Women from 2.0 to below 3.0 mg/dL
Whether causative or a risk marker, we suggest that the range of SUA normal values should be examined carefully. Physicochemical properties define hyperuricemia as levels above the solubility threshold (6.8 mg/dL), defining an increased risk of kidney stones, urate nephropathy, and gout. With regard to cardiovascular and metabolic sequel, lower values are already associated with an increased risk.
Your True Normal Uric Acid Range
So now you can compare your uric acid blood test results with a true normal range. Then consult your doctor if your results are higher. Because you need to ask your doctor to check for all the diseases associated with high uric acid – not just gout.
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True Normal Uric Acid Range References
- Shani, Michal, Shlomo Vinker, Dganit Dinour, Merav Leiba, Gilad Twig, Eliezer J. Holtzman, and Adi Leiba. “High normal uric acid levels are associated with an increased risk of diabetes in lean, normoglycemic healthy women.” The Journal of Clinical Endocrinology & Metabolism 101, no. 10 (2016): 3772-3778.